Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Dcx  doublecortin   (Synonyms: Dbct, lissencephaly, X-linked (doublecortin))
Results	Reference
1	J:137346 Arbour N, Vanderluit JL, Le Grand JN, Jahani-Asl A, Ruzhynsky VA, Cheung EC, Kelly MA, MacKenzie AE, Park DS, Opferman JT, Slack RS, Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage. J Neurosci. 2008 Jun 11;28(24):6068-78
1	J:113146 Cappello S, Attardo A, Wu X, Iwasato T, Itohara S, Wilsch-Brauninger M, Eilken HM, Rieger MA, Schroeder TT, Huttner WB, Brakebusch C, Gotz M, The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat Neurosci. 2006 Sep;9(9):1099-107
1	J:182669 Cappello S, Bohringer CR, Bergami M, Conzelmann KK, Ghanem A, Tomassy GS, Arlotta P, Mainardi M, Allegra M, Caleo M, van Hengel J, Brakebusch C, Gotz M, A radial glia-specific role of RhoA in double cortex formation. Neuron. 2012 Mar 8;73(5):911-24
1	J:88495 Chae TH, Kim S, Marz KE, Hanson PI, Walsh CA, The hyh mutation uncovers roles for alpha Snap in apical protein localization and control of neural cell fate. Nat Genet. 2004 Mar;36(3):264-70
1	J:299855 Cheng YY, Chou YT, Lai FJ, Jan MS, Chang TH, Jou IM, Chen PS, Lo JY, Huang SS, Chang NS, Liou YT, Hsu PC, Cheng HC, Lin YS, Hsu LJ, Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3beta-mediated epileptic seizure activity in mice. Acta Neuropathol Commun. 2020 Jan 30;8(1):6
1	J:325357 Chomiak AA, Guo Y, Kopsidas CA, McDaniel DP, Lowe CC, Pan H, Zhou X, Zhou Q, Doughty ML, Feng Y, Nde1 is required for heterochromatin compaction and stability in neocortical neurons. iScience. 2022 Jun 17;25(6):104354
1	J:274335 Draganova K, Zemke M, Zurkirchen L, Valenta T, Cantu C, Okoniewski M, Schmid MT, Hoffmans R, Gotz M, Basler K, Sommer L, Wnt/beta-catenin signaling regulates sequential fate decisions of murine cortical precursor cells. Stem Cells. 2015 Jan;33(1):170-82
1	J:328712 Du H, Wang Z, Guo R, Yang L, Liu G, Zhang Z, Xu Z, Tian Y, Yang Z, Li X, Chen B, Transcription factors Bcl11a and Bcl11b are required for the production and differentiation of cortical projection neurons. Cereb Cortex. 2022 Aug 22;32(17):3611-3632
1	J:226378 Falk S, Joosten E, Kaartinen V, Sommer L, Smad4 and Trim33/Tif1gamma redundantly regulate neural stem cells in the developing cortex. Cereb Cortex. 2014 Nov;24(11):2951-63
1	J:94756 Feng Y, Walsh CA, Mitotic spindle regulation by Nde1 controls cerebral cortical size. Neuron. 2004 Oct 14;44(2):279-93
1	J:218049 Houlihan SL, Feng Y, The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation. Elife. 2014;3:e03297
1	J:220901 Hu WF, Pomp O, Ben-Omran T, Kodani A, Henke K, Mochida GH, Yu TW, Woodworth MB, Bonnard C, Raj GS, Tan TT, Hamamy H, Masri A, Shboul M, Al Saffar M, Partlow JN, Al-Dosari M, Alazami A, Alowain M, Alkuraya FS, Reiter JF, Harris MP, Reversade B, Walsh CA, Katanin p80 regulates human cortical development by limiting centriole and cilia number. Neuron. 2014 Dec 17;84(6):1240-57
1*	J:326587 Hurley S, Mohan C, Suetterlin P, Ellingford R, Riegman KLH, Ellegood J, Caruso A, Michetti C, Brock O, Evans R, Rudari F, Delogu A, Scattoni ML, Lerch JP, Fernandes C, Basson MA, Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development. Mol Autism. 2021 Feb 24;12(1):16
1	J:259920 Ju J, Liu Q, Zhang Y, Liu Y, Jiang M, Zhang L, He X, Peng C, Zheng T, Lu QR, Li H, Olig2 regulates Purkinje cell generation in the early developing mouse cerebellum. Sci Rep. 2016 Jul 29;6:30711
1	J:243635 Khacho M, Clark A, Svoboda DS, MacLaurin JG, Lagace DC, Park DS, Slack RS, Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis. Hum Mol Genet. 2017 Sep 01;26(17):3327-3341
1	J:160624 Kim S, Lehtinen MK, Sessa A, Zappaterra MW, Cho SH, Gonzalez D, Boggan B, Austin CA, Wijnholds J, Gambello MJ, Malicki J, LaMantia AS, Broccoli V, Walsh CA, The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron. 2010 Apr 15;66(1):69-84
1	J:197131 Lanctot AA, Peng CY, Pawlisz AS, Joksimovic M, Feng Y, Spatially dependent dynamic MAPK modulation by the nde1-lis1-brap complex patterns Mammalian CNS. Dev Cell. 2013 May 13;25(3):241-55
1*	J:276389 Li M, Zhao X, Wang W, Shi H, Pan Q, Lu Z, Perez SP, Suganthan R, He C, Bjoras M, Klungland A, Ythdf2-mediated m(6)A mRNA clearance modulates neural development in mice. Genome Biol. 2018 May 31;19(1):69
1	J:123223 Markham K, Schuurmans C, Weiss S, STAT5A/B activity is required in the developing forebrain and spinal cord. Mol Cell Neurosci. 2007 Jun;35(2):272-82
1	J:238369 Mihalas AB, Elsen GE, Bedogni F, Daza RA, Ramos-Laguna KA, Arnold SJ, Hevner RF, Intermediate Progenitor Cohorts Differentially Generate Cortical Layers and Require Tbr2 for Timely Acquisition of Neuronal Subtype Identity. Cell Rep. 2016 Jun 28;16(1):92-105
1	J:187391 Pacal M, Bremner R, Mapping differentiation kinetics in the mouse retina reveals an extensive period of cell cycle protein expression in post-mitotic newborn neurons. Dev Dyn. 2012 Oct;241(10):1525-44
1	J:176173 Passemard S, El Ghouzzi V, Nasser H, Verney C, Vodjdani G, Lacaud A, Lebon S, Laburthe M, Robberecht P, Nardelli J, Mani S, Verloes A, Gressens P, Lelievre V, VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling. J Clin Invest. 2011 Aug 1;121(8):3071-87
1	J:138579 Pawlisz AS, Mutch C, Wynshaw-Boris A, Chenn A, Walsh CA, Feng Y, Lis1-Nde1-dependent neuronal fate control determines cerebral cortical size and lamination. Hum Mol Genet. 2008 Aug 15;17(16):2441-55
1	J:255488 Premarathne S, Murtaza M, Matigian N, Jolly LA, Wood SA, Loss of Usp9x disrupts cell adhesion, and components of the Wnt and Notch signaling pathways in neural progenitors. Sci Rep. 2017 Aug 14;7(1):8109
1*	J:291475 Roychoudhury K, Salomone J, Qin S, Cain B, Adam M, Potter SS, Nakafuku M, Gebelein B, Campbell K, Physical interactions between Gsx2 and Ascl1 balance progenitor expansion versus neurogenesis in the mouse lateral ganglionic eminence. Development. 2020 Apr 10;147(7):dev185348
1	J:159625 Silver DL, Watkins-Chow DE, Schreck KC, Pierfelice TJ, Larson DM, Burnetti AJ, Liaw HJ, Myung K, Walsh CA, Gaiano N, Pavan WJ, The exon junction complex component Magoh controls brain size by regulating neural stem cell division. Nat Neurosci. 2010 May;13(5):551-8
1	J:204287 Stegeman S, Jolly LA, Premarathne S, Gecz J, Richards LJ, Mackay-Sim A, Wood SA, Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFbeta-mediated axonogenesis. PLoS One. 2013;8(7):e68287
1	J:137649 Thompson JA, Zembrzycki A, Mansouri A, Ziman M, Pax7 is requisite for maintenance of a subpopulation of superior collicular neurons and shows a diverging expression pattern to Pax3 during superior collicular development. BMC Dev Biol. 2008;8:62
1	J:243678 Zemke M, Draganova K, Klug A, Scholer A, Zurkirchen L, Gay MH, Cheng P, Koseki H, Valenta T, Schubeler D, Basler K, Sommer L, Loss of Ezh2 promotes a midbrain-to-forebrain identity switch by direct gene derepression and Wnt-dependent regulation. BMC Biol. 2015 Nov 30;13:103
1	J:275567 Zurkirchen L, Varum S, Giger S, Klug A, Hausel J, Bossart R, Zemke M, Cantu C, Atak ZK, Zamboni N, Basler K, Sommer L, Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Nat Commun. 2019 May 16;10(1):2192